The clinical studies** on Fensebiome™ peptide focus on its effectiveness in promoting skin microbiota diversity, enhancing skin barrier function, and protecting the skin from environmental and chemical stressors, including hand sanitizers.

In Vivo Clinical Studies

1. Study 1: Microbiome Diversity

• Participants: 21 female volunteers (aged 18-59) from urban areas in Barcelona, Spain.
• Method: Application of cream containing 1% Fensebiome™ peptide on the cubital fossa (forearm) twice daily for 7 days. Placebo was applied to the opposite arm.
• Results:
  • Microbial Diversity: The Shannon index revealed a significant increase in microbial diversity, indicating healthier skin microbiota.
  • Microbial Composition: The peptide promoted a balance between Firmicutes and Proteobacteria, favoring anti-inflammatory strains (e.g., Moraxellaceae) while reducing strains linked to skin conditions (e.g., Staphylococcaceae).

Parameter	% Change
Microbial Diversity	Significant increase (p<0.01)
Anti-inflammatory bacteria (Proteobacteria)	Increase (p<0.05)

2. Study 2: Enhanced Skin Cell Cohesion

• Participants: 18 female volunteers (aged 26-50) with dry skin from Barcelona, Spain.
• Method: 1% Fensebiome™ peptide applied twice daily on the shin for 7 days. Skin cohesion measured by corneocyte desquamation.
• Results: Reduced skin scaliness by 18.6%, showing improved skin cell cohesion and sensitivity restoration.

Parameter	% Reduction
Skin Scaliness	18.6% (p<0.05)

3. Study 3: Barrier Protection Against Surfactants

• Participants: 20 female volunteers (aged 22-45) from Portugal.
• Method: Application of Fensebiome™ peptide on the forearm followed by damage induced with sodium lauryl sulfate. The transepidermal water loss (TEWL) was measured after 7 days.
• Results: TEWL significantly decreased, indicating improved skin barrier protection.

TEWL	% Reduction
Transepidermal Water Loss	Significant reduction (p<0.0001)

Conclusion:

Fensebiome™ peptide effectively improves skin health by increasing microbiota diversity, promoting beneficial bacterial adhesion, enhancing skin barrier protection, and restoring sensitive skin through increased cell cohesion and hydration.

**As per the data sheet supplied. Juhst has not conducted these clinical studies on the peptide.

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